Application of silymarin in human and animal medicine
نویسندگان
چکیده
Silymarin, the polyphenolic fraction from Milk Thistle (Silybum marianum) and its main component silybinin, are used almost exclusively for hepatoprotection in humans. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It effects, by antioxidative, anti-inflammatory, antifibrotic, antilipid peroxidative, membrane stabilizing and liver regenerating mechanisms. Its clinical applications in humans comprise therapy in alcoholic liver diseases, liver cirrhosis, Amanita mushroom poisoning, viral hepatitis, toxic and drug-induced liver diseases. Recognition of new silymarin derivatives opens new ways for its application in liver therapy. Silymarin application in veterinary medicine is also reviewed.
منابع مشابه
Effects of Silymarin on Growth Performance, Internal Organs and Some Blood Parameters in Japanese Quail Subjected to Oxidative Stress Induced by Carbon Tetrachloride
The effects of Silymarin on growth performance, internal organs, and some blood parameters were investigated in Japanese quail that were subjected to oxidative stress induced by carbon tetrachloride (CCl4). An experiment was conducted as a completely randomized design in a factorial arrangement (2 × 2) with four replicates of 30 birds each. Factors included two levels of Silymarin (0 and 1 mL/k...
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